Nylidrin Hydrochloride: A Reference Standard for Peripheral Vascular Drug Quality Control

 Nylidrin Hydrochloride, also known by its synonym Buphenine Hydrochloride, is a beta-adrenergic agonist historically used as a peripheral vasodilator to improve blood flow in conditions such as peripheral vascular disease and Raynaud's phenomenon. Whether supporting legacy manufacturing lines or ongoing analytical reference work, a well-characterized standard for the compound itself is essential for labs working with this API.

What Is Nylidrin Hydrochloride?

Nylidrin Hydrochloride is chemically identified as 4-(1-Hydroxy-2-((4-phenylbutan-2-yl)amino)propyl)phenol hydrochloride — the hydrochloride salt form of Nylidrin, commonly required for identity confirmation, potency testing, and impurity profiling in pharmaceutical quality work.

Key specifications:

  • CAT No: SZ-N100001
  • CAS No: 849-55-8
  • Molecular Formula: C19H25NO2 : HCl
  • Molecular Weight: 299.4 : 36.5
  • Related CAS No: 447-41-6 (free base)
  • Synonym: Buphenine Hydrochloride
  • Availability: Synthesis on demand
  • Shipping Condition: Room temperature

Why This Reference Standard Matters

Reference standards like Nylidrin Hydrochloride support a range of pharmaceutical quality and research applications, including:

  • Analytical method development and validation (AMV): building reliable HPLC/LC-MS methods for identity and assay testing
  • Quality control (QC) testing: confirming batch identity and potency during manufacturing
  • ANDA and DMF filing support: supplying the authentic reference material regulators expect in submission dossiers
  • Forced degradation studies: characterizing how the compound behaves under stress conditions
  • Impurity identification: anchoring comparison against related compounds and degradation products during method development

Sourcing Nylidrin Hydrochloride

SynZeal's Nylidrin Hydrochloride reference standard is supplied with detailed characterization data compliant with regulatory guidelines, and traceability against USP or EP pharmacopeial standards can be provided based on feasibility. As with all SynZeal reference materials, it is intended strictly for laboratory, research, and analytical use, not for human consumption.

Nylidrin sits within SynZeal's broader portfolio of vasodilator and cardiovascular-related reference standards, supporting labs that need authentic comparator material for both legacy and current analytical programs.

Explore More

For labs working across cardiovascular and other therapeutic areas, it's worth browsing the full SynZeal product catalog, which spans thousands of pharmacopeial and non-pharmacopeial reference standards, metabolites, and stable isotope-labelled compounds across major therapeutic categories.

This article is for general informational purposes and does not constitute regulatory or medical advice. This compound is intended strictly for laboratory, research, and analytical use, not for human consumption. Product availability, CAS numbers, and specifications should always be verified directly on the manufacturer's website before ordering.

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